Intervening in glial cells protects neurons in Parkinson's model

Stressed dopaminergic neurons call nearby glial cells for help. Those calls can over-activate the glial cells resulting in a cascade of inflammatory signaling that, over time, contributes to neuronal degradation. Working in two fly models of Parkinson's, researchers characterized a novel mechanism that orchestrates this cascade and demonstrated that disrupting it protects neurons as they age. The research provides a new understanding of Parkinson's pathology and offers an alternative approach for developing preventative treatments.

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