Dying cancer cells make remaining glioblastoma cells more aggressive and therapy-resistant

A surprising form of cell-to-cell communication in glioblastoma promotes global changes in recipient cells, including aggressiveness, motility, and resistance to radiation or chemotherapy. Paradoxically, the sending cells in this signaling are glioblastoma cells undergoing programmed cell death. The apoptotic cancer cells release extracellular vesicles. These vesicle, or exosomes, carry components that alter RNA splicing in the recipient glioblastoma cells, and this altered splicing promotes therapy resistance and aggressive migration.

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