Mechanism underlying malformation associated with severe epilepsy is revealed

Study suggests dysregulation of gene NEUROG2 could be linked to development of focal cortical dysplasia, one of the most common causes of drug-resistant epilepsy. NEUROG2 is involved in cell differentiation and, when overexpressed, it maintains the neurogenesis signal active into adulthood, what helps explaining the presence of abnormal neurons and glial cells in patients' brains.

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