TGen discovers potential drug targets to reduce pain in pancreatic cancer patients

TGen researchers have found that nerve growth factor (NGF), a neurotrophic factor, and its receptor TRKA are associated with perineural invasion, which is the ability of pancreatic cancer cells to invade surrounding nerves. Blocking the NGF signaling through inhibitors of NGF and TRKA reduces the potential of pancreatic cancer cells to migrate towards the surrounding nerves, according to a TGen study published in the scientific journal PLOS ONE.

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