Global DS Foundation funds research showing impact of trisomy 21 on interferon signaling

Renowned Crnic Institute scientist, Dr. Espinosa, has found the interferon response is constantly activated in people with Down syndrome causing the body to fight a viral infection when such infection doesn't exist. Constant immune system activation would likely cause damaging side-effects and may explain cognitive deficit, increased prevalence of autoimmune disorders, higher risk of Alzheimer's disease, and protection against solid tumors. Testing FDA-approved drugs that block the interferon response could be an important next step.

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